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Brain Human Monoclonal Autoantibody from Sydenham Chorea Targets Dopaminergic Neurons in Transgenic Mice and Signals Dopamine D2 Receptor: Implications in Human Disease

How autoantibodies target the brain and lead to disease in disorders such as Sydenham chorea (SC) is not known. SC is characterized by autoantibodies against the brain and is the main neurologic manifestation of streptococcal-induced rheumatic fever. Previously, our novel SC-derived mAb 24.3.1 was f...

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Bibliografski detalji
Glavni autori: Cox, Carol J., Sharma, Meenakshi, Leckman, James F., Zuccolo, Jonathan, Zuccolo, Amir, Kovoor, Abraham, Swedo, Susan E., Cunningham, Madeleine W.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848617/
https://ncbi.nlm.nih.gov/pubmed/24184556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102592
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