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Is mTOR inhibition a systemic treatment for tuberous sclerosis?
Tuberous sclerosis complex (TSC) is a genetic multisystem disorder characterized by the development of hamartomas in several organs. Mutations in the TSC1 and TSC2 tumor suppressor genes determin overactivation of the mammalian target of rapamycin (mTOR) signaling pathway and subsequent abnormalitie...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3848592/ https://ncbi.nlm.nih.gov/pubmed/24044547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1824-7288-39-57 |
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