Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro

BACKGROUND: Familial hyperaldosteronism type I (FH-I) is caused by the unequal recombination between the 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes, resulting in the generation of a CYP11B1/B2 chimeric gene and abnormal adrenal aldosterone production. Affected patients usu...

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Detalhes bibliográficos
Main Authors: Vecchiola, Andrea, Lagos, Carlos F, Fuentes, Cristóbal A, Allende, Fidel, Campino, Carmen, Valdivia, Carolina, Tapia-Castillo, Alejandra, Ogishima, Tadashi, Mukai, Kuniaki, Owen, Gareth, Solari, Sandra, Carvajal, Cristian A, Fardella, Carlos E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848474/
https://ncbi.nlm.nih.gov/pubmed/23938178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-7827-11-76
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