Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge

Modified vaccinia virus Ankara (MVA), developed >30 years ago as a highly attenuated candidate smallpox vaccine, was recloned from a 1974 passage and evaluated for safety and immunogenicity. Replication of MVA is impaired in most mammalian cells, and we found that mice with severe combined immunodef...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wyatt, Linda S., Earl, Patricia L., Eller, Leigh Anne, Moss, Bernard
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2004
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384791/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15070762/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401165101
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