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Metagenes and molecular pattern discovery using matrix factorization

We describe here the use of nonnegative matrix factorization (NMF), an algorithm based on decomposition by parts that can reduce the dimension of expression data from thousands of genes to a handful of metagenes. Coupled with a model selection mechanism, adapted to work for any stochastic clustering...

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Detalhes bibliográficos
Main Authors: Brunet, Jean-Philippe, Tamayo, Pablo, Golub, Todd R., Mesirov, Jill P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC384712/
https://ncbi.nlm.nih.gov/pubmed/15016911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308531101
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