A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay

In eukaryotes, a surveillance mechanism known as nonsense-mediated decay (NMD) degrades the mRNA when a premature-termination codon (PTC) is present. NMD requires translation to read the frame of the mRNA and detect the PTC. During pre-mRNA splicing, the exon–exon junction complex (EJC) is recruited...

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Detaylı Bibliyografya
Asıl Yazarlar: Ferraiuolo, Maria A., Lee, Chung-Sheng, Ler, Lian Wee, Hsu, Jeanne L., Costa-Mattioli, Mauro, Luo, Ming-Juan, Reed, Robin, Sonenberg, Nahum
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC384704/
https://ncbi.nlm.nih.gov/pubmed/15024115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400933101
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