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Methotrexate treatment of FraX fibroblasts results in FMR1 transcription but not in detectable FMR1 protein levels
BACKGROUND: Fragile X syndrome is caused by the loss of FMRP expression due to methylation of the FMR1 promoter. Treatment of fragile X syndrome patients’ lymphoblastoid cells with 5-azadeoxycytidine results in demethylation of the promoter and reactivation of the gene. The aim of the study was to a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3846751/ https://ncbi.nlm.nih.gov/pubmed/24020679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1866-1955-5-23 |
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