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Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway

Matrix elasticity regulates proliferation, apoptosis, and differentiation of many cell types across various tissues. In particular, stiffened matrix in fibrotic lesions has been shown to promote pathogenic myofibroblast activation. To better understand the underlying pathways by which fibroblasts me...

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Detalhes bibliográficos
Main Authors: Wang, Huan, Tibbitt, Mark W., Langer, Stephen J., Leinwand, Leslie A., Anseth, Kristi S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845151/
https://ncbi.nlm.nih.gov/pubmed/24218588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306369110
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