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Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase

Long-term depression (LTD) reduces the functional strength of excitatory synapses through mechanisms that include the removal of AMPA glutamate receptors from the postsynaptic membrane. LTD induction is also known to result in structural changes at excitatory synapses, including the shrinkage of den...

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Autors principals: Lee, Hyejin, Lee, Eun-Jae, Song, Yoo Sung, Kim, Eunjoon
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843889/
https://ncbi.nlm.nih.gov/pubmed/24298159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2013.0158
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