The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages()

Agglomeration dramatically affects many aspects of nanoparticle–cell interactions. Here we show that hydroxyapatite nanoparticles formed large agglomerates in biological medium resulting in extensive particle uptake and dose-dependent cytotoxicity in human macrophages. Particle citration and/or the...

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Bibliographic Details
Main Authors: Müller, Karin H., Motskin, Michael, Philpott, Alistair J., Routh, Alexander F., Shanahan, Catherine M., Duer, Melinda J., Skepper, Jeremy N.
Format: Artigo
Language:Inglês
Published: Elsevier Science 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843813/
https://ncbi.nlm.nih.gov/pubmed/24183166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2013.10.041
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