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Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60
The Cdk2 inhibitor, p27(Kip1), is degraded in a phosphorylation- and ubiquitylation-dependent manner at the G(1)–S transition of the cell cycle. Degradation of p27(Kip1) requires import into the nucleus for phosphorylation by Cdk2. Phosphorylated p27(Kip1) is thought to be subsequently re-exported a...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2000
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC384374/ https://ncbi.nlm.nih.gov/pubmed/10811608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.10.2168 |
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