Both Positive and Negative Selection Pressures Contribute to the Polymorphism Pattern of the Duplicated Human CYP21A2 Gene

The human steroid 21-hydroxylase gene (CYP21A2) participates in cortisol and aldosterone biosynthesis, and resides together with its paralogous (duplicated) pseudogene in a multiallelic copy number variation (CNV), called RCCX CNV. Concerted evolution caused by non-allelic gene conversion has been d...

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Main Authors: Szabó, Julianna Anna, Szilágyi, Ágnes, Doleschall, Zoltán, Patócs, Attila, Farkas, Henriette, Prohászka, Zoltán, Rácz, Kárioly, Füst, George, Doleschall, Márton
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843699/
https://ncbi.nlm.nih.gov/pubmed/24312389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081977
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