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Conformational dynamics is more important than helical propensity for the folding of the all α-helical protein Im7
Im7 folds via an on-pathway intermediate that contains three of the four native α-helices. The missing helix, helix III, is the shortest and its failure to be formed until late in the pathway is related to frustration in the structure. Im7H3M3, a 94-residue variant of the 87-residue Im7 in which hel...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3843627/ https://ncbi.nlm.nih.gov/pubmed/24123274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2372 |
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