Inadequate T follicular cell help impairs B cell immunity during HIV infection

The majority of HIV infected individuals fail to produce protective antibodies and have diminished responses to immunization(1–3). We report that even though there is an expansion of T follicular helper (Tfh) cells in HIV infected individuals, these are unable to provide adequate B cell help. A high...

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Detalhes bibliográficos
Main Authors: Cubas, Rafael A., Mudd, Joseph C., Savoye, Anne-Laure, Perreau, Matthieu, van Grevenynghe, Julien, Metcalf, Talibah, Connick, Elizabeth, Meditz, Amie, Freeman, Gordon J., Abesada-Terk, Guillermo, Jacobson, Jeffrey M., Brooks, Ari D., Crotty, Shane, Estes, Jacob D., Pantaleo, Giuseppe, Lederman, Michael M., Haddad, Elias K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843317/
https://ncbi.nlm.nih.gov/pubmed/23475201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3109
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