Dynamic mitochondrial–nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation

Glucocorticoids play an important role in adipogenesis through the glucocorticoid receptor (GR) that forms a heterocomplex with Hsp90•Hsp70 and one high molecular weight immunophilin, either FKBP51 or FKBP52. When 3T3-L1 preadipocytes are induced to differentiate, FKBP51 expression progressively inc...

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Bibliographic Details
Main Authors: Toneatto, Judith, Guber, Sergio, Charó, Nancy L., Susperreguy, Sebastián, Schwartz, Jessica, Galigniana, Mario D., Piwien-Pilipuk, Graciela
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843136/
https://ncbi.nlm.nih.gov/pubmed/24101724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.125799
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