Distinct Roles of the Phosphatidate Phosphatases Lipin 1 and 2 during Adipogenesis and Lipid Droplet Biogenesis in 3T3-L1 Cells

Lipins are evolutionarily conserved Mg(2+)-dependent phosphatidate phosphatase (PAP) enzymes with essential roles in lipid biosynthesis. Mammals express three paralogues: lipins 1, 2, and 3. Loss of lipin 1 in mice inhibits adipogenesis at an early stage of differentiation and results in a lipodystr...

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Main Authors: Sembongi, Hiroshi, Miranda, Merce, Han, Gil-Soo, Fakas, Stylianos, Grimsey, Neil, Vendrell, Joan, Carman, George M., Siniossoglou, Symeon
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Lipids
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843065/
https://ncbi.nlm.nih.gov/pubmed/24133206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.488445
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