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Release of initiation control by a mutational alteration in the R6K pi protein required for plasmid DNA replication.

Plasmid pRK419, a derivative of the naturally occurring antibiotic resistance plasmid R6K, contains the pir gene that codes for the pi initiation protein and the beta and gamma replication origins of R6K. A mutation in plasmid pRK419, designated cos405, results in an elevated plasmid copy number in...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Stalker, D M, Filutowicz, M, Helinski, D R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1983
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384285/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6310578/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.18.5500
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