Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives

BACKGROUND: The emergence of Plasmodium falciparum resistance to artemisinins in Southeast Asia threatens the control of malaria worldwide. The pharmacodynamic hallmark of artemisinin derivatives is rapid parasite clearance (a short parasite half-life), therefore, the in vivo phenotype of slow clear...

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Detalhes bibliográficos
Main Authors: Flegg, Jennifer A, Guérin, Philippe J, Nosten, Francois, Ashley, Elizabeth A, Phyo, Aung Pyae, Dondorp, Arjen M, Fairhurst, Rick M, Socheat, Duong, Borrmann, Steffen, Björkman, Anders, Mårtensson, Andreas, Mayxay, Mayfong, Newton, Paul N, Bethell, Delia, Se, Youry, Noedl, Harald, Diakite, Mahamadou, Djimde, Abdoulaye A, Hien, Tran T, White, Nicholas J, Stepniewska, Kasia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842737/
https://ncbi.nlm.nih.gov/pubmed/24225303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-12-411
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