Surfactant protein D (SP-D) deficiency is attenuated in humanised mice expressing the Met(11)Thr short nucleotide polymorphism of SP-D: implications for surfactant metabolism in the lung

Surfactant protein D (SP-D) is part of the innate immune system involved in lung homeostasis. SP-D knockout mice show accumulations of foamy alveolar macrophages, alveolar lipoproteinosis and pulmonary emphysema. Three single nucleotide polymorphisms (SNPs) have been described in the coding sequence...

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Main Authors: Knudsen, Lars, Ochs, Katharina, Boxler, Laura, Tornoe, Ida, Lykke-Sorensen, Grith, Mackay, Rose-Marie, Clark, Howard W, Holmskov, Uffe, Ochs, Matthias, Madsen, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842200/
https://ncbi.nlm.nih.gov/pubmed/24111992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/joa.12120
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