High Yields of Oligodendrocyte Lineage Cells from Human Embryonic Stem Cells at Physiological Oxygen Tensions for Evaluation of Translational Biology

We have established and efficient system to specify NG2/PDGF-Rα/OLIG2+ oligodendrocyte precursor cells (OPCs) from human embryonic stem cells (hESCs) at low, physiological (3%) oxygen levels. This was achieved via both forebrain and spinal cord origins, with up to 98% of cells expressing NG2. Develo...

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Autori principali: Stacpoole, Sybil R.L., Spitzer, Sonia, Bilican, Bilada, Compston, Alastair, Karadottir, Ragnhildur, Chandran, Siddharthan, Franklin, Robin J.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841262/
https://ncbi.nlm.nih.gov/pubmed/24286031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.09.006
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