Effects of dipeptidyl peptidase-4 inhibition in an animal model of experimental asthma: a matter of dose, route, and time

The CD26-associated enzymatic activity of dipeptidyl peptidase-4 (DPP4) as well as the recruitment of CD26(+) T cells increase under allergic airway inflammation. Furthermore, genetic deficiency of CD26/DPP4 exerts protective effects in experimental asthma. Therefore, CD26/DPP4 might represent a nov...

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Autors principals: Stephan, Michael, Suhling, Hendrik, Schade, Jutta, Wittlake, Mareike, Tasic, Tihana, Klemann, Christian, Pabst, Reinhard, Jurawitz, Marie-Charlot, Raber, Kerstin A, Hoymann, Heinz G, Braun, Armin, Glaab, Thomas, Hoffmann, Torsten, Schmiedl, Andreas, von Hörsten, Stephan
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841031/
https://ncbi.nlm.nih.gov/pubmed/24303167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phy2.95
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