Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease, and the lack of effective therapy results in inevitable death within a few years of onset. Failure of GluA2 RNA editing resulting from downregulation of the RNA-editing enzyme adenosine deaminase acting on RNA 2...

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Detalhes bibliográficos
Main Authors: Yamashita, Takenari, Chai, Hui Lin, Teramoto, Sayaka, Tsuji, Shoji, Shimazaki, Kuniko, Muramatsu, Shin-ichi, Kwak, Shin
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840487/
https://ncbi.nlm.nih.gov/pubmed/24115583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201302935
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