Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease, and the lack of effective therapy results in inevitable death within a few years of onset. Failure of GluA2 RNA editing resulting from downregulation of the RNA-editing enzyme adenosine deaminase acting on RNA 2...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Yamashita, Takenari, Chai, Hui Lin, Teramoto, Sayaka, Tsuji, Shoji, Shimazaki, Kuniko, Muramatsu, Shin-ichi, Kwak, Shin
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840487/
https://ncbi.nlm.nih.gov/pubmed/24115583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201302935
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky