Identification of the molecular defect in factor IX Chapel Hill: substitution of histidine for arginine at position 145.

Hemophilia B Chapel Hill is a mild hereditary hemorrhagic disorder in which the factor IX antigen is present in normal amounts but factor IX biological activity is markedly reduced. Previous studies have demonstrated that purified factor IX Chapel Hill has 8% of the activity of normal human factor I...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Noyes, C M, Griffith, M J, Roberts, H R, Lundblad, R L
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1983
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384004/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6603618/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.14.4200
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