Tumor-Specific Chromosome Mis-Segregation Controls Cancer Plasticity by Maintaining Tumor Heterogeneity

Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 (Chr7) copy number variation (CNV) in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-...

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Hoofdauteurs: Hu, Yuanjie, Ru, Ning, Xiao, Huasheng, Chaturbedi, Abhishek, Hoa, Neil T., Tian, Xiao-Jun, Zhang, Hang, Ke, Chao, Yan, Fengrong, Nelson, Jodi, Li, Zhenzhi, Gramer, Robert, Yu, Liping, Siegel, Eric, Zhang, Xiaona, Jia, Zhenyu, Jadus, Martin R., Limoli, Charles L., Linskey, Mark E., Xing, Jianhua, Zhou, Yi-Hong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839911/
https://ncbi.nlm.nih.gov/pubmed/24282558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080898
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