HLA-A*31:01 and HLA-B*15:02 as genetic markers for carbamazepine hypersensitivity in children

The occurrence of hypersensitivity reactions including rare but life-threatening Stevens-Johnson syndrome (SJS) and drug-induced hypersensitivity syndrome (HSS) limits the use of the anticonvulsant carbamazepine (CBZ). HLA-B*15:02 and HLA-A*31:01 have been identified as predictive genetic markers fo...

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Main Authors: Amstutz, Ursula, Ross, Colin J.D., Castro-Pastrana, Lucila I., Rieder, Michael J., Shear, Neil H., Hayden, Michael R., Carleton, Bruce C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839910/
https://ncbi.nlm.nih.gov/pubmed/23588310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.55
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