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Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy
Duchenne muscular dystrophy, a fatal degenerative muscle disease, is caused by mutations in the dystrophin gene. Loss of dystrophin in the muscle cell membrane causes muscle fiber necrosis. Previously, loss-of-function mutations in dys-1, the Caenorhabditis elegans dystrophin ortholog, were shown to...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839758/ https://ncbi.nlm.nih.gov/pubmed/24191049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308866110 |
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