Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing

We explored the detection of genome-wide hypomethylation in plasma using shotgun massively parallel bisulfite sequencing as a marker for cancer. Tumor-associated copy number aberrations (CNAs) could also be observed from the bisulfite DNA sequencing data. Hypomethylation and CNAs were detected in th...

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Hauptverfasser: Chan, K. C. Allen, Jiang, Peiyong, Chan, Carol W. M., Sun, Kun, Wong, John, Hui, Edwin P., Chan, Stephen L., Chan, Wing Cheong, Hui, David S. C., Ng, Simon S. M., Chan, Henry L. Y., Wong, Cesar S. C., Ma, Brigette B. Y., Chan, Anthony T. C., Lai, Paul B. S., Sun, Hao, Chiu, Rossa W. K., Lo, Y. M. Dennis
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839703/
https://ncbi.nlm.nih.gov/pubmed/24191000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313995110
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