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ELEVATED GLUCOSE AND FATTY ACID LEVELS IMPAIR SUBSTANCE P–INDUCED DERMAL MICROVASCULAR ENDOTHELIAL CELL MIGRATION AND PROLIFERATION IN AN AGAROSE GEL MODEL SYSTEM
Substance P (SP), a sensory nerve derived neuropeptide, has been implicated in wound repair. Our hypothesis was that oxidative effects of elevated glucose and fatty acid levels as seen with diabetes mellitus inhibit SP-mediated endothelial cell directional migration and proliferation. Using a 2% aga...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3838914/ https://ncbi.nlm.nih.gov/pubmed/19295489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e3181a1cb2e |
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