FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis

FOXO transcription factors are central regulators of longevity from worms to humans. FOXO3 – the FOXO isoform associated with exceptional human longevity – preserves adult neural stem cell pools. Here we identify FOXO3 direct targets genome-wide in primary cultures of adult neural progenitor cells (...

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Bibliografiska uppgifter
Huvudupphovsmän: Webb, Ashley E., Pollina, Elizabeth A., Vierbuchen, Thomas, Urbán, Noelia, Ucar, Duygu, Leeman, Dena S., Martynoga, Ben, Sewak, Madhavi, Rando, Thomas A., Guillemot, François, Wernig, Marius, Brunet, Anne
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838667/
https://ncbi.nlm.nih.gov/pubmed/23891001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.06.035
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