The P2Y(6) Receptor Mediates Clostridium difficile Toxin-Induced CXCL8/IL-8 Production and Intestinal Epithelial Barrier Dysfunction

C. difficile is a Gram-positive spore-forming anaerobic bacterium that is the leading cause of nosocomial diarrhea in the developed world. The pathogenesis of C. difficile infections (CDI) is driven by toxin A (TcdA) and toxin B (TcdB), secreted factors that trigger the release of inflammatory media...

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Bibliographic Details
Main Authors: Hansen, Ashleigh, Alston, Laurie, Tulk, Sarah E., Schenck, L. Patrick, Grassie, Michael E., Alhassan, Basmah F., Veermalla, Arun Teja, Al-Bashir, Samir, Gendron, Fernand-Pierre, Altier, Christophe, MacDonald, Justin A., Beck, Paul L., Hirota, Simon A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838400/
https://ncbi.nlm.nih.gov/pubmed/24278446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081491
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