A Two-Pronged Structural Analysis of Retroviral Maturation Indicates that Core Formation Proceeds by a Disassembly-Reassembly Pathway Rather than a Displacive Transition

Retrovirus maturation involves sequential cleavages of the Gag polyprotein, initially arrayed in a spherical shell, leading to formation of capsids with polyhedral or conical morphology. Evidence suggests that capsids assemble de novo inside maturing virions from dissociated capsid (CA) protein, but...

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Detalhes bibliográficos
Main Authors: Keller, Paul W., Huang, Rick K., England, Matthew R., Waki, Kayoko, Cheng, Naiqian, Heymann, J. Bernard, Craven, Rebecca C., Freed, Eric O., Steven, Alasdair C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838239/
https://ncbi.nlm.nih.gov/pubmed/24109217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01408-13
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