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beta-Endorphin: synthesis of analogs modified at the carboxyl terminus with increased activites.

Three analogs of human beta-endorphin (beta h-EP) have been synthesized: [Gly31]beta h-EP, [Gly31]beta h-endorphinamide, and [Gly31]beta h-endorphinylglycine. All are more active than beta h-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are abou...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Li, C H, Yamashiro, D, Tseng, L F, Chang, W C, Ferrara, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1979
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383807/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/226965/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.7.3276
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