Isavuconazole (BAL4815) Pharmacodynamic Target Determination in an In Vivo Murine Model of Invasive Pulmonary Aspergillosis against Wild-Type and cyp51 Mutant Isolates of Aspergillus fumigatus

Invasive pulmonary aspergillosis (IPA) continues to rise in concert with increasing numbers of immune suppression techniques to treat other medical conditions and transplantation. Despite these advances, morbidity and mortality rates remain unacceptably high. One strategy used to optimize outcomes i...

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Autori principali: Lepak, Alexander J., Marchillo, Karen, VanHecker, Jamie, Andes, David R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837846/
https://ncbi.nlm.nih.gov/pubmed/24100500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01355-13
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