Early Growth Response-1 (EGR-1) and Nuclear Factor of Activated T Cells (NFAT) Cooperate to Mediate CD40L Expression in Megakaryocytes and Platelets

Increasing evidence implicates circulating platelets as mediators of chronic inflammatory and autoimmune diseases via the expression and release of CD40L, an important modulator of inflammation and adaptive immune responses traditionally associated with activated T cells. Emerging evidence suggests...

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Bibliographic Details
Main Authors: Crist, Scott A., Elzey, Bennett D., Ahmann, Michelle T., Ratliff, Timothy L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837138/
https://ncbi.nlm.nih.gov/pubmed/24106272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.511881
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