Two-sided Ubiquitin Binding of NF-κB Essential Modulator (NEMO) Zinc Finger Unveiled by a Mutation Associated with Anhidrotic Ectodermal Dysplasia with Immunodeficiency Syndrome

Hypomorphic mutations in the X-linked human NEMO gene result in various forms of anhidrotic ectodermal dysplasia with immunodeficiency. NEMO function is mediated by two distal ubiquitin binding domains located in the regulatory C-terminal domain of the protein: the coiled-coil 2-leucine zipper (CC2-...

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Detalhes bibliográficos
Main Authors: Ngadjeua, Flora, Chiaravalli, Jeanne, Traincard, François, Raynal, Bertrand, Fontan, Elisabeth, Agou, Fabrice
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837117/
https://ncbi.nlm.nih.gov/pubmed/24100029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.483305
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