Monopolar Spindle 1 (MPS1) Protein-dependent Phosphorylation of RecQ-mediated Genome Instability Protein 2 (RMI2) at Serine 112 Is Essential for BLM-Topo III α-RMI1-RMI2 (BTR) Protein Complex Function upon Spindle Assembly Checkpoint (SAC) Activation during Mitosis

Genomic instability and a predisposition to cancer are hallmarks of Bloom syndrome, an autosomal recessive disease arising from mutations in the BLM gene. BLM is a RecQ helicase component of the BLM-Topo III α-RMI1-RMI2 (BTR) complex, which maintains chromosome stability at the spindle assembly chec...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pradhan, Arun, Singh, Thiyam Ramsing, Ali, Abdullah Mahmood, Wahengbam, Kebola, Meetei, Amom Ruhikanta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837099/
https://ncbi.nlm.nih.gov/pubmed/24108125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470823
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados