Demonstration of low density lipoprotein receptors in mouse teratocarcinoma stem cells and description of a method for producing receptor-deficient mutant mice

Familial hypercholesterolemia, a widespread human genetic disorder implicated in vascular and coronary disease, has had no laboratory animal counterpart that would enable the pathogenesis to be analyzed and drugs to be tested in vivo. The primary lesion in some patients is known to occur in the cell...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Goldstein, Joseph L., Brown, Michael S., Krieger, Monty, Anderson, Richard G. W., Mintz, Beatrice
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1979
Subjects:
Biological Sciences: Cell Biology
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383705/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/223161/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.6.2843
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