Direct Effects of TNF-α on Local Fuel Metabolism and Cytokine Levels in the Placebo-Controlled, Bilaterally Infused Human Leg: Increased Insulin Sensitivity, Increased Net Protein Breakdown, and Increased IL-6 Release

Tumor necrosis factor-α (TNF-α) has widespread metabolic actions. Systemic TNF-α administration, however, generates a complex hormonal and metabolic response. Our study was designed to test whether regional, placebo-controlled TNF-α infusion directly affects insulin resistance and protein breakdown....

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Detalhes bibliográficos
Main Authors: Bach, Ermina, Nielsen, Roni R., Vendelbo, Mikkel H., Møller, Andreas B., Jessen, Niels, Buhl, Mads, K- Hafstrøm, Thomas, Holm, Lars, Pedersen, Steen B., Pilegaard, Henriette, Biensø, Rasmus S., Jørgensen, Jens O.L., Møller, Niels
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837036/
https://ncbi.nlm.nih.gov/pubmed/23835341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0138
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