Correlation of Chromosomal Instability, Telomere Length and Telomere Maintenance in Microsatellite Stable Rectal Cancer: A Molecular Subclass of Rectal Cancer

INTRODUCTION: Colorectal cancer (CRC) tumor DNA is characterized by chromosomal damage termed chromosomal instability (CIN) and excessively shortened telomeres. Up to 80% of CRC is microsatellite stable (MSS) and is historically considered to be chromosomally unstable (CIN+). However, tumor phenotyp...

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Detalhes bibliográficos
Main Authors: Boardman, Lisa A., Johnson, Ruth A., Viker, Kimberly B., Hafner, Kari A., Jenkins, Robert B., Riegert-Johnson, Douglas L., Smyrk, Thomas C., Litzelman, Kristin, Seo, Songwon, Gangnon, Ronald E., Engelman, Corinne D., Rider, David N., Vanderboom, Russell J., Thibodeau, Stephen N., Petersen, Gloria M., Skinner, Halcyon G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836975/
https://ncbi.nlm.nih.gov/pubmed/24278232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080015
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