Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors

ErbB2 tyrosine kinase inhibitors (TKI) block tyrosine autophosphorylation and activation of the full-length transmembrane ErbB2 receptor (p185(ErbB2)). In addition to p185(ErbB2) truncated forms of ErbB2 exist in breast cancer cell lines and clinical tumors. The contribution of these truncated forms...

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Hoofdauteurs: Xia, Wenle, Zuguo, Liu, Zong, Rongrong, Liu, Leihua, Zhao, Sumin, Bacus, Sarah, Mao, Yubin, He, Jia, D, Julia, Wulfkuhle, Petricoin, Emanuel F., Osada, Takuya, Yang, Xiaoyi, Hartman, Zachary, Clay, Timothy, Blackwell, Kimberly, Lyerly, Kim, Spector, Neil L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836594/
https://ncbi.nlm.nih.gov/pubmed/21673090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0991
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