Molecular Dynamic Simulation to Explore the Molecular Basis of Btk-PH Domain Interaction with Ins(1,3,4,5)P4

Bruton's tyrosine kinase contains a pleckstrin homology domain, and it specifically binds inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), which is involved in the maturation of B cells. In this paper, we studied 12 systems including the wild type and 11 mutants, K12R, S14F, K19E, R28C/H, E...

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Autores principales: Lu, Dan, Jiang, Junfeng, Liang, Zhongjie, Sun, Maomin, Luo, Cheng, Shen, Bairong, Hu, Guang
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836457/
https://ncbi.nlm.nih.gov/pubmed/24307874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/580456
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