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miRNAs confer phenotypic robustness to gene networks by suppressing biological noise

miRNAs are small non-coding RNAs able to modulate target-gene expression. It has been postulated that miRNAs confer robustness to biological processes, but a clear experimental evidence is still missing. Using a synthetic biology approach, we demonstrate that microRNAs provide phenotypic robustness...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Siciliano, Velia, Garzilli, Immacolata, Fracassi, Chiara, Criscuolo, Stefania, Ventre, Simona, di Bernardo, Diego
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836244/
https://ncbi.nlm.nih.gov/pubmed/24077216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3364
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