Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.

Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. When incubated with deoxyadenosine or thymidine, the malignant T cell lines rapidly accumulate toxic concentrations of dATP and dTTP, respec...

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Bibliografiske detaljer
Main Authors: Carson, D A, Kaye, J, Matsumoto, S, Seegmiller, J E, Thompson, L
Format: Artigo
Sprog:Inglês
Udgivet: 1979
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC383615/
https://ncbi.nlm.nih.gov/pubmed/313056
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