Maternal Dietary Restriction During the Periconceptional Period in Normal-Weight or Obese Ewes Results in Adrenocortical Hypertrophy, an Up-Regulation of the JAK/STAT and Down-Regulation of the IGF1R Signaling Pathways in the Adrenal of the Postnatal Lamb

Maternal dietary restriction during the periconceptional period results in an increase in adrenal growth and in the cortisol stress response in the offspring. The intraadrenal mechanisms that result in the programming of these changes are not clear. Activation of the IGF and the signal transducer an...

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Main Authors: Zhang, Song, Morrison, Janna L., Gill, Amreet, Rattanatray, Leewen, MacLaughlin, Severence M., Kleemann, David, Walker, Simon K., McMillen, I. Caroline
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Glucocorticoids-CRH-ACTH-Adrenal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836080/
https://ncbi.nlm.nih.gov/pubmed/24108072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1414
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