Thrombospondin 1 Mediates High-Fat Diet-Induced Muscle Fibrosis and Insulin Resistance in Male Mice

Thrombospondin 1 (THBS1 or TSP-1) is a circulating glycoprotein highly expressed in hypertrophic visceral adipose tissues of humans and mice. High-fat diet (HFD) feeding induces the robust increase of circulating THBS1 in the early stages of HFD challenge. The loss of Thbs1 protects male mice from d...

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Detalhes bibliográficos
Main Authors: Inoue, Mayumi, Jiang, Yibin, Barnes, Richard H., Tokunaga, Masakuni, Martinez-Santibañez, Gabriel, Geletka, Lynn, Lumeng, Carey N., Buchner, David A., Chun, Tae-Hwa
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Energy Balance-Obesity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836064/
https://ncbi.nlm.nih.gov/pubmed/24140711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1587
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