Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia

Vascular endothelial growth factor A (VEGFA) isoform treatment has been demonstrated to alter spermatogonial stem cell homeostasis. Therefore, we generated pDmrt1-Cre;Vegfa(−/−) (knockout, KO) mice by crossing pDmrt1-Cre mice to floxed Vegfa mice to test whether loss of all VEGFA isoforms in Sertoli...

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Detalhes bibliográficos
Main Authors: Lu, Ningxia, Sargent, Kevin M., Clopton, Debra T., Pohlmeier, William E., Brauer, Vanessa M., McFee, Renee M., Weber, John S., Ferrara, Napoleone, Silversides, David W., Cupp, Andrea S.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Reproduction-Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836063/
https://ncbi.nlm.nih.gov/pubmed/24169552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1363
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