The Effects of Testosterone Deprivation and Supplementation on Proteasomal and Autophagy Activity in the Skeletal Muscle of the Male Mouse: Differential Effects on High-Androgen Responder and Low-Androgen Responder Muscle Groups

Men with prostate cancer who receive androgen deprivation therapy show profound skeletal muscle loss. We hypothesized that the androgen deficiency activates not only the ubiquitin-proteasome systems but also the autophagy and affects key aspects of the molecular cross talk between protein synthesis...

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Bibliographic Details
Main Authors: Serra, Carlo, Sandor, Nicolae Lucian, Jang, Hyeran, Lee, Daniel, Toraldo, Gianluca, Guarneri, Tyler, Wong, Siu, Zhang, Anqi, Guo, Wen, Jasuja, Ravi, Bhasin, Shalender
Format: Artigo
Language:Inglês
Published: Endocrine Society 2013
Subjects:
General Endocrinology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836062/
https://ncbi.nlm.nih.gov/pubmed/24105483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1004
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