Acetate Supplementation Induces Growth Arrest of NG2/PDGFRα-Positive Oligodendroglioma-Derived Tumor-Initiating Cells

Cancer is associated with globally hypoacetylated chromatin and considerable attention has recently been focused on epigenetic therapies. N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acet...

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Detalhes bibliográficos
Main Authors: Long, Patrick M., Tighe, Scott W., Driscoll, Heather E., Moffett, John R., Namboodiri, Aryan M. A., Viapiano, Mariano S., Lawler, Sean E., Jaworski, Diane M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835562/
https://ncbi.nlm.nih.gov/pubmed/24278309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080714
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