Mutational and Structural Analyses of Caldanaerobius polysaccharolyticus Man5B Reveal Novel Active Site Residues for Family 5 Glycoside Hydrolases

CpMan5B is a glycoside hydrolase (GH) family 5 enzyme exhibiting both β-1,4-mannosidic and β-1,4-glucosidic cleavage activities. To provide insight into the amino acid residues that contribute to catalysis and substrate specificity, we solved the structure of CpMan5B at 1.6 Å resolution. The structu...

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Autori principali: Oyama, Takuji, Schmitz, George E., Dodd, Dylan, Han, Yejun, Burnett, Alanna, Nagasawa, Naoko, Mackie, Roderick I., Nakamura, Haruki, Morikawa, Kosuke, Cann, Isaac
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835425/
https://ncbi.nlm.nih.gov/pubmed/24278284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080448
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