Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues

[Image: see text] The natural product withaferin A exhibits potent antitumor activity and other diverse pharmacological activities. The recently discovered withalongolide A, a C-19 hydroxylated congener of withaferin A, was recently reported to possess cytotoxic activity against head and neck squamo...

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Bibliographic Details
Main Authors: Motiwala, Hashim F., Bazzill, Joseph, Samadi, Abbas, Zhang, Huaping, Timmermann, Barbara N., Cohen, Mark S., Aubé, Jeffrey
Format: Artigo
Language:Inglês
Published: American Chemical Society 2013
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835334/
https://ncbi.nlm.nih.gov/pubmed/24273633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400267q
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